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The earliest phases of the high-mass star-forming regions (HMSFRs) have so many extremely complicated astrophysical processes, such as infall and outflows, fragmentations that kinematic studies are not enough to understand all the mysteries, therefore, chemistry has developed into a powerful tool in probing the nature of them.
Using the interferometers (PdBI, SMA), combined with the single dished telescopes (IRAM 30 m), we studied several well-known HMSFRs: Orion-KL, NGC7538 S and IRAS1. At 1.3 mm, continuums for these sources are presented, and substructures /fragmentations are resolved with the high spatial resolution <1000 AU. Spectra from all the substructures in each source are extracted and the intensity-integrated distribution maps for several different species are imaged. Column density and abundance for each species are calculated spatially, and chemical differentiation within each source are suggested due to different reasons.
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